zk in the Real World: Verifying Cancer Research

From December 9 to December 13, the Nexus network operated in a testnet phase, providing participants worldwide an opportunity to connect as nodes and contribute computational power. This phase served as a critical step in evaluating the performance of the Nexus zero-knowledge virtual machine (zkVM), a foundational component designed to power a next-generation global distributed supercomputer.

The Nexus network, alongside the Nexus zkVM, represents a transformative leap in distributed computing infrastructure. By enabling rapid verification of data and computations, this emerging supercomputer aims to unlock groundbreaking possibilities in data processing and verification, ultimately making a new kind of Internet possible.

Exploring real-world impact through testnet trials

Over the five-day testnet period, numerous capabilities were tested, including a trial designed to generate proofs with tangible real-world applications. A fraction of the testnet’s overall computational cycles were dedicated to verifying a statistical model used in breast cancer research.

Specifically, the testnet trial verified a logistic regression model, a common machine learning approach for predictive analytics. The underlying model was trained on data from the Wisconsin Breast Cancer Database — a dataset frequently leveraged by researchers for studies and experiments — to analyze biopsy images and determine whether specific data patterns correlated with cancer diagnoses. Such applications hold immense potential for early detection and intervention in breast cancer treatment.

The primary objective of including data from this model in the Nexus testnet was to provide verifiable proof that the model operates as intended, which could ultimately establish trust in its results.

Testnet trial results: The network successfully verified the model’s computations, demonstrating its capability to handle significant applications in a distributed environment.

Linking computation verification to broader medical applications

Although this test focused on a single record from the dataset, the implications are far-reaching. By leveraging distributed supercomputing to support medical research, we can enhance the reliability and efficiency of machine learning and artificial intelligence (AI) in critical applications.

As AI increasingly influences decision-making processes, ensuring the provenance and integrity of data models becomes paramount. Establishing a robust “data supply chain”— linking model results to their computational origins — helps maintain quality control and transparency throughout the process. This parallels other sectors, such as transportation and agriculture, where traceability mechanisms like vehicle identification numbers (VINs) or QR codes on food ensure accountability.

For the breast cancer model verified during the testnet, associating proofs of correctness with computational results not only enhances trust in diagnostic tools but also sets the stage for more reliable applications of machine learning and AI in healthcare and beyond. Future research will be able to rely on verified data and models, which will increase the overall quality of the data pipeline, ultimately resulting in more reliable outcomes.

Accelerating verification with distributed computing

Traditional computational verification has been a resource-intensive endeavor. For instance, verifying the cancer diagnostic model locally on a high-performance laptop, such as the latest MacBook Pro, requires approximately 2.5 hours. However, by distributing the workload across the Nexus supercomputer’s global nodes, the same task can be completed significantly faster.

This distributed approach not only reduces time but also generates portable proofs that remain attached to the underlying computation. This capability introduces a powerful mechanism for monitoring and maintaining the integrity of data workflows.

Toward a Verifiable Internet

The inclusion of the breast cancer model in the testnet represents an early milestone in the journey toward building verifiable services and the broader vision of a Verifiable Internet. By ensuring the correctness of computations, the Nexus network paves the way for a future where data-driven processes are inherently trustworthy and transparent.

As we continue to develop this distributed supercomputer, we invite researchers, developers, and innovators to contribute to upcoming testnets.

Together, we can advance the boundaries of verifiable computing and unlock new possibilities for a data-driven world.

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